Research on World Agricultural Economy

A Comprehensive Review on the Production, Cultural, and Medicinal Applications of Cannabis Plant for Sustainable Economic Development

Azile Dumani

Department of Biological and Environmental Sciences, Faculty of Natural Science, Walter Sisulu University, Mthatha 5099, South Africa; Department of Rural Development and Agrarian Reform, Döhne Agricultural Development Institute, Stutterheim 4930, South Africa

Ifeanyi Egbichi

Department of Biological and Environmental Sciences, Faculty of Natural Science, Walter Sisulu University,

Mthatha 5099, South Africa

Tembakazi Theodora Silwana

Department of Rural Development and Agrarian Reform, Döhne Agricultural Development Institute, Stutterheim 4930, South Africa

Babalwa Mpambani

Department of Rural Development and Agrarian Reform, Döhne Agricultural Development Institute, Stutterheim 4930, South Africa

Olwetu Antonia Sindesi

Independent Researcher, Idutywa 5000, South Africa

Hlabana Alfred Seepe

Quarantine Station, Department of Agriculture, Land Reform & Rural Development, Stellenbosch 7600, South Africa

DOI: https://doi.org/10.36956/rwae.v7i2.2570

Received: 2 August 2025 | Revised: 17 September 2025| Accepted: 23 September 2025 | Published Online: 7 April 2026

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Abstract

Cannabis sativa is a versatile plant which is recognized as an exceptional carbon sink and sustainable biofuel that addresses economic, environmental, and social dimensions. Its cultivation has  historically been prohibited in many countries due to its psychoactive effects. However, the global movement towards the legalisation and decriminalisation for its medicinal and industrial uses has recently intensified, prompting new research into its botanical, ecological, and agronomic aspects. This review explored the available scientific information for a holistic and understanding of the Cannabis’ medicinal and industrial applications. The review applied a systematic literature review guided by PRISMA principles to synthesize published work on Cannabis sativa. Peer-reviewed and grey literature were sourced from multiple databases and repositories using defined keywords.  No lower time limit was applied, and literature coverage published work up to December 2023. After screening 625 records, 180 studies were retained and thematically grouped into six areas: historical or cultural significance, legality, botanical and chemical characterization, agronomic practices, medicinal potential, and economic contributions. A narrative synthesis highlighted key findings, contradictions, and knowledge gaps, while noting potential biases such as English-only sources and uneven geographic representation. The study further discussed the historical overview of cannabis, current global scenarios and legality issues, classification concerning botany and cannabinoid contents, agronomic and ecological practices, chemical composition, its biological activities, and economic importance. The study concludes that by balancing economic growth with environmental stewardship and cultural preservation, cannabis can be a promising cornerstone crop for sustainable development in South Africa and globally in the 21st century.

Keywords: Cannabis sativa; Medicinal; Industrial; Economy; Classification; Ecology; Legality Status; Cannabinoids

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References

[1] Zheng, Z., Fiddes, K., Yang, L., 2021. A narrative review on environmental impacts of cannabis cultivation. Journal of Cannabis Research. 3(1), 35. DOI: https://doi.org/10.1186/s42238-021-00090-0

[2] Kafka, D.C., 2025. The 2018 Farm Bill’s Hemp Definition and Legal Challenges to State Laws Restricting Certain THC Products. Available from: https://www.congress.gov/crs-product/R48637 (cited 16 June 2025).

[3] Freeman, D., Dunn, G., Murray, R.M., et al., 2015. How Cannabis Causes Paranoia: Using the Intravenous Administration of ∆ 9 -Tetrahydrocannabinol (THC) to Identify Key Cognitive Mechanisms Leading to Paranoia. Schizophrenia Bulletin. 41(2), 391–399. DOI: https://doi.org/10.1093/schbul/sbu098

[4] Kramer, J.L., 2015. Medical marijuana for cancer. CA: A Cancer Journal for Clinicians. 65(2), 109–122. DOI: https://doi.org/10.3322/caac.21260

[5] Landis, H., Hicks, K., Cockson, P., et al., 2019. Expanding Leaf Tissue Nutrient Survey Ranges for Greenhouse Cannabidiol-Hemp. Crop, Forage & Turfgrass Management. 5(1), 180081. DOI: https://doi.org/10.2134/cftm2018.09.0081

[6] Bar-Lev Schleider, L., Mechoulam, R., Lederman, V., et al., 2018. Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer. European Journal of Internal Medicine. 49, 37–43. DOI: https://doi.org/10.1016/j.ejim.2018.01.023

[7] Duvall, C.S., 2019. A brief agricultural history of cannabis in Africa, from prehistory to canna-colony. EchoGéo. 48. DOI: https://doi.org/10.4000/echogeo.17599

[8] Giraudo, R.F., 2020. Cannabis Culture on Display: Deviant Heritage Comes Out of the Shadows. Museum Worlds. 8(1), 7–24. DOI: https://doi.org/10.3167/armw.2020.080103

[9] Zarei, A., Feyissa, B.A., Davis, B., et al., 2022. Cannabis Synthetic Seeds: An Alternative Approach for Commercial Scale of Clonal Propagation and Germplasm Conservation. Plants. 11(23), 3186. DOI: https://doi.org/10.3390/plants11233186

[10] Wartenberg, A.C., Holden, P.A., Bodwitch, H., et al., 2021. Cannabis and the Environment: What Science Tells Us and What We Still Need to Know. Environmental Science & Technology Letters. 8(2), 98–107. DOI: https://doi.org/10.1021/acs.estlett.0c00844

[11] Kepe, T., 2003. Cannabis sativa and rural livelihoods in South Africa: politics of cultivation, trade and value in Pondoland. Development Southern Africa. 20(5), 605–615. DOI: https://doi.org/10.1080/0376835032000149252

[12] Cockson, P., Barajas, G., Whipker, B., 2019. Enhancing Rooting of Vegetatively Propagated Cannabis sativa ‘BaOx’ Cuttings. Journal of Agricultural Hemp Research. 1(1). DOI: https://doi.org/10.61611/2688-5182.1000

[13] Carah, J.K., Howard, J.K., Thompson, S.E., et al., 2015. High time for conservation: adding the environment to the debate on marijuana liberalization. BioScience. 65(8), 822–829. Available from: https://crc.berkeley.edu/wp-content/uploads/2019/06/carah-high-time-for-conservation.pdf

[14] Eisenstein, T.K., Meissler, J.J., 2015. Effects of Cannabinoids on T-cell Function and Resistance to Infection. Journal of Neuroimmune Pharmacology. 10(2), 204–216. DOI: https://doi.org/10.1007/s11481-015-9603-3

[15] Short Gianotti, A.G., Harrower, J., Baird, G., et al., 2017. The quasi-legal challenge: Assessing and governing the environmental impacts of cannabis cultivation in the North Coastal Basin of California. Land Use Policy. 61, 126–134. DOI: https://doi.org/10.1016/j.landusepol.2016.11.016

[16] Caplan, D., Dixon, M., Zheng, Y., 2017. Optimal Rate of Organic Fertilizer during the Flowering Stage for Cannabis Grown in Two Coir-based Substrates. HortScience. 52(12), 1796–1803. DOI: https://doi.org/10.21273/HORTSCI12401-17

[17] Shiponi, S., Bernstein, N., 2021. Response of medical cannabis (Cannabis sativa L.) genotypes to P supply under long photoperiod: Functional phenotyping and the ionome. Industrial Crops and Products. 161, 113154. DOI: https://doi.org/10.1016/j.indcrop.2020.113154

[18] Butsic, V., Carah, J.K., Baumann, M., et al., 2018. The emergence of cannabis agriculture frontiers as environmental threats. Environmental Research Letters. 13(12), 124017. DOI: https://doi.org/10.1088/1748-9326/aaeade

[19] Pennisi, E., 2017. A new neglected crop: cannabis. Science. 356(6335), 232–233. DOI: https://doi.org/10.1126/science.356.6335.232

[20] Small, E., 2015. Evolution and Classification of Cannabis sativa (Marijuana, Hemp) in Relation to Human Utilization. The Botanical Review. 81(3), 189–294. DOI: https://doi.org/10.1007/s12229-015-9157-3

[21] Monthony, A.S., Kyne, S.T., Grainger, C.M., et al., 2020. Recalcitrance of Cannabis sativa to de novo regeneration; a multi-genotype replication study. DOI: https://doi.org/10.1101/2020.06.23.167478

[22] Chandra, S., Lata, H., ElSohly, M.A., et al., 2017. Cannabis cultivation: Methodological issues for obtaining medical-grade product. Epilepsy & Behavior. 70, 302–312. DOI: https://doi.org/10.1016/j.yebeh.2016.11.029

[23] Stack, G.M., Toth, J.A., Carlson, C.H., et al., 2020. Evaluation of high-CBD cultivars in New York State: Results of 2020 Cornell hemp field trials. Available from: https://bpb-us-e1.wpmucdn.com/blogs.cornell.edu/dist/a/7491/files/2021/05/2020CBDTrialReport_2021.02.19.pdf (cited 15 May 2025).

[24] Punja, Z.K., 2021. Emerging diseases of Cannabis sativa and sustainable management. Pest Management Science. 77(9), 3857–3870. DOI: https://doi.org/10.1002/ps.6307

[25] Caproni, L., Raggi, L., Negri, V., 2020. In situ landrace propagation management and access guidelines. Available from: https://more.bham.ac.uk/farmerspride/wp-content/uploads/sites/19/2020/09/D2.4_In_situ_landrace_propagation_management_guidelines.pdf (cited 28 May 2025).

[26] Raggi, L., Caproni, L., Carboni, A., et al., 2019. Genome-Wide Association Study Reveals Candidate Genes for Flowering Time Variation in Common Bean (Phaseolus vulgaris L.). Frontiers in Plant Science. 10, 962. DOI: https://doi.org/10.3389/fpls.2019.00962

[27] Thormann, I., Reeves, P., Thumm, S., et al., 2017. Genotypic and phenotypic changes in wild barley (Hordeum vulgare subsp. spontaneum) during a period of climate change in Jordan. Genetic Resources and Crop Evolution. 64(6), 1295–1312. DOI: https://doi.org/10.1007/s10722-016-0437-5

[28] Small, E., 2017. Cannabis. A complete guide. CRC Press: Boca Raton, FL, USA.

[29] Caplan, D.M., 2018. Propagation and root zone management for controlled environment Cannabis production [PhD’s thesis]. University of Guelph: Guelph, ON, Canada. Available from: https://atrium.lib.uoguelph.ca/items/35a1bb18-ce23-4908-86c7-7ae800bd1ebc

[30] Punja, Z.K., 2018. Flower and foliage-infecting pathogens of marijuana ( Cannabis sativa L.) plants. Canadian Journal of Plant Pathology. 40(4), 514–527. DOI: https://doi.org/10.1080/07060661.2018.1535467

[31] Merlin, M., 2017. Cannabis: A Complete Guide. Economic Botany. 71(4), 388–390. Available from: https://www.jstor.org/stable/45171712

[32] Russo, E.B., 2011. Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects. British Journal of Pharmacology. 163(7), 1344–1364. DOI: https://doi.org/10.1111/j.1476-5381.2011.01238.x

[33] Struik, P.C., Amaducci, S., Bullard, M.J., et al., 2000. Agronomy of fibre hemp (Cannabis sativa L.) in Europe. Industrial Crops and Products. 11(2–3), 107–118. DOI: https://doi.org/10.1016/S0926-6690(99)00048-5

[34] Weihrauch, R., 2021. Criminalising cannabis in South Africa: a history and post-Prince discussion [Master's thesis]. University of Cape Town: Cape Town, South Africa. Available from: http://hdl.handle.net/11427/33974

[35] Peltzer, K., Ramlagan, S., 2007. Cannabis use trends in South Africa. South African Journal of Psychiatry. 13(4), 6. DOI: https://doi.org/10.4102/sajpsychiatry.v13i4.33

[36] Clarke, R., Merlin, M., 2019. Cannabis: Evolution and Ethnobotany. University of California Press: downtown Oakland, CA, USA. DOI: https://doi.org/10.1525/9780520954571

[37] Sofowora, A., Ogunbodede, E., Onayade, A., 2013. The role and place of medicinal plants in the strategies for disease prevention. African Journal of Traditional, Complementary and Alternative Medicines. 10(5), 210–229. DOI: https://doi.org/10.4314/ajtcam.v10i5.2

[38] Pollio, A., 2016. The Name of Cannabis : A Short Guide for Nonbotanists. Cannabis and Cannabinoid Research. 1(1), 234–238. DOI: https://doi.org/10.1089/can.2016.0027

[39] Radwan, M.M., Chandra, S., Gul, S., et al., 2021. Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis. Molecules. 26(9), 2774. DOI: https://doi.org/10.3390/molecules26092774

[40] Kowalski, K.M., 2016. Decriminalization of Cannabis—High Time to Revisit Prince [Master’s thesis]. University of Cape Town: Cape Town, South Africa. Available from: http://hdl.handle.net/11427/20868

[41] Francois, T., 1974. The Dagga Problem: A sociological perspective with special Reference to the question of social policy [Master’s thesis] University of Cape Town: Cape Town, South Africa. Available from: http://hdl.handle.net/11427/15420

[42] Craig, P., 2009. Prohibition & Resistance: A Socio-Political Exploration of the Changing Dynamics of the Southern African Cannabis Trade, c. 1850—the present [Master’s thesis]. Rhodes University: Makhanda, South Africa. Available from: http://hdl.handle.net/10962/d1002403

[43] Pujol, J., Blanco-Hinojo, L., Batalla, A., et al., 2014. Functional connectivity alterations in brain networks relevant to self-awareness in chronic cannabis users. Journal of Psychiatric Research. 51, 68–78. DOI: https://doi.org/10.1016/j.jpsychires.2013.12.008

[44] Bewley-Taylor, D., Blickman, T., Jelsma, M., 2014. The rise and decline of cannabis prohibition. The history of cannabis in the UN drug control system and options for reform. Global Drug Policy Observatory/Transnational Institute: Amsterdam, Netherlands.

[45] Bewley-Taylor, D., Jelsma, M., 2012. The Limits of Latitude-The UN Drug Control Conventions. Available from: https://www.tni.org/en/publication/the-limits-of-latitude (cited 06 May 2025).

[46] Republic of South Africa, 1983. Conservation of Agricultural Resources Act 43 of 1983. Available from: https://www.gov.za/documents/conservation-agricultural-resources-act-1-apr-2015-0926 (cited 14 May 2025).

[47] Brunetti, P., Pichini, S., Pacifici, R., et al., 2020. Herbal Preparations of Medical Cannabis: A Vademecum for Prescribing Doctors. Medicina. 56(5), 237. DOI: https://doi.org/10.3390/medicina56050237

[48] Nkosi, P.I., 2019. Dagga in Mid-Century South Africa: Impacts of Criminalization and Policing. Available from: https://ujcontent.uj.ac.za/esploro/outputs/graduate/Dagga-in-mid-century-South-Africa/9912302107691 (cited 29 May 2025).

[49] Parry, C., Myers, B., Caulkins, J., 2019. Decriminalisation of recreational cannabis in South Africa. The Lancet. 393(10183), 1804–1805. DOI: https://doi.org/10.1016/S0140-6736(19)30011-X

[50] Kitchen, C., Kabba, J.A., Fang, Y., 2022. Status and Impacts of Recreational and Medicinal Cannabis Policies in Africa: A Systematic Review and Thematic Analysis of Published and “Gray” Literature. Cannabis and Cannabinoid Research. 7(3), 239–261. DOI: https://doi.org/10.1089/can.2021.0110

[51] Rychert, M., Emanuel, M.A., Wilkins, C., 2021. Foreign investment in emerging legal medicinal cannabis markets: the Jamaica case study. Globalization and Health. 17(1), 38. DOI: https://doi.org/10.1186/s12992-021-00687-3

[52] Jalali, S., Salami, S.A., Sharifi, M., et al., 2019. Signaling compounds elicit expression of key genes in cannabinoid pathway and related metabolites in cannabis. Industrial Crops and Products. 133, 105–110. DOI: https://doi.org/10.1016/j.indcrop.2019.03.004

[53] Kuddus, M., Ginawi, I., AlHazimi, A., 2013. Cannabis sativa: An ancient wild edible plant of India. Emirates Journal of Food and Agriculture. 25(10), 736. DOI: https://doi.org/10.9755/ejfa.v25i10.16400

[54] Lawrence, R.G., 2019. Pot in pans: A history of eating cannabis. Rowman & Littlefield: Lanham, MD, USA.

[55] Zuk-Golaszewska, K., Golaszewski, J., 2018. Cannabis sativa L.—cultivation and quality of raw material. Journal of Elementology. 23(3). Available from: https://www.researchgate.net/publication/325638140_Cannabis_sativa_L_-_cultivation_and_quality_of_raw_material

[56] Potter, D.J., 2014. A review of the cultivation and processing of cannabis ( Cannabis sativa L.) for production of prescription medicines in the UK. Drug Testing and Analysis. 6(1–2), 31–38. DOI: https://doi.org/10.1002/dta.1531

[57] Nemati, R., Fortin, J.-P., Craig, J., et al., 2021. Growing Mediums for Medical Cannabis Production in North America. Agronomy. 11(7), 1366. DOI: https://doi.org/10.3390/agronomy11071366

[58] Klumpers, L.E., Thacker, D.L., 2019. A Brief Background on Cannabis: From Plant to Medical Indications. Journal of AOAC INTERNATIONAL. 102(2), 412–420. DOI: https://doi.org/10.5740/jaoacint.18-0208

[59] Johnson, R., 2014. Hemp as an agricultural commodity. Available from: https://www.congress.gov/crs-product/RL32725 (cited 29 June 2025).

[60] Techen, N., Chandra, S., Lata, H., et al., 2010. Genetic Identification of Female Cannabis sativa Plants at Early Developmental Stage. Planta Medica. 76(16), 1938–1939. DOI: https://doi.org/10.1055/s-0030-1249978

[61] Hanuš, L.O., Levy, R., De La Vega, D., et al., 2016. The main cannabinoids content in hashish samples seized in Israel and Czech Republic. Israel Journal of Plant Sciences. 63(3), 182–190. DOI: https://doi.org/10.1080/07929978.2016.1177983

[62] Farag, S., Kayser, O., 2017. The Cannabis Plant: Botanical Aspects. in: Handbook of Cannabis and Related Pathologies. Elsevier: London, UK. pp. 3–12. DOI: https://doi.org/10.1016/B978-0-12-800756-3.00001-6

[63] Kim, S., 2024. Genetic and Environmental Factors Shaping Cannabis Phenotypes A Study on Temperature Effects and Genetic Regulation of Anthocyanin Accumulation in Cannabis sativa [PhD’s thesis]. University of Wisconsin: Madison, WI, USA.

[64] Zuk-Golaszewska, K., Golasszewski, J., 2020. Hemp production. In: Crini, G., Lichtfouse, E. (Eds.). Sustainable Agriculture Reviews 42: Hemp Production and Applications, Sustainable Agriculture Reviews. Springer International Publishing,: Cham, Switzerland. pp. 1–36. DOI: https://doi.org/10.1007/978-3-030-41384-2

[65] Trancoso, I., De Souza, G.A.R., Dos Santos, P.R., et al., 2022. Cannabis sativa L.: Crop Management and Abiotic Factors That Affect Phytocannabinoid Production. Agronomy. 12(7), 1492. DOI: https://doi.org/10.3390/agronomy12071492

[66] Ahsan, S.M., Injamum-Ul-Hoque, Md., Shaffique, S., et al., 2024. Illuminating Cannabis sativa L.: The Power of Light in Enhancing C. sativa Growth and Secondary Metabolite Production. Plants. 13(19), 2774. DOI: https://doi.org/10.3390/plants13192774

[67] Kumar, R., Singh, A.K., Kanawjia, A., 2023. Medicinal and Aromatic Crops HFL 311. Banda University of Agriculture and Technology: Banda, India.

[68] Sharma, U.C., Datta, M., Sharma, V., 2025. Chemistry, Microbiology, and Behaviour of Acid Soils. In: Soil Acidity, Progress in Soil Science. Springer Nature: Cham, Switzerland. pp. 121–322. DOI: https://doi.org/10.1007/978-3-031-76357-1_3

[69] Thakur Babita Kanwar, R., 2023. An Overview of Flowering Pot Plants for Tropical and Subtropical Climate. International Journal of Science and Research (IJSR). 12(7), 1274–1280. DOI: https://doi.org/10.21275/SR23713104357

[70] Massuela, D.C., Munz, S., Hartung, J., et al., 2023. Cannabis Hunger Games: nutrient stress induction in flowering stage—impact of organic and mineral fertilizer levels on biomass, cannabidiol (CBD) yield and nutrient use efficiency. Frontiers in Plant Science. 14, 1233232. DOI: https://doi.org/10.3389/fpls.2023.1233232

[71] Park, S.-H., Pauli, C.S., Gostin, E.L., et al., 2022. Effects of short-term environmental stresses on the onset of cannabinoid production in young immature flowers of industrial hemp (Cannabis sativa L.). Journal of Cannabis Research. 4(1), 1. DOI: https://doi.org/10.1186/s42238-021-00111-y

[72] Baldini, M., Ferfuia, C., Zuliani, F., et al., 2020. Suitability assessment of different hemp (Cannabis sativa L.) varieties to the cultivation environment. Industrial Crops and Products. 143, 111860. DOI: https://doi.org/10.1016/j.indcrop.2019.111860

[73] Jin, D., Jin, S., Chen, J., 2019. Cannabis Indoor Growing Conditions, Management Practices, and Post-Harvest Treatment: A Review. American Journal of Plant Sciences. 10(06), 925–946. DOI: https://doi.org/10.4236/ajps.2019.106067

[74] Chandra, S., Lata, H., Khan, I.A., et al., 2011. Temperature response of photosynthesis in different drug and fiber varieties of Cannabis sativa L. Physiology and Molecular Biology of Plants. 17(3), 297–303. DOI: https://doi.org/10.1007/s12298-011-0068-4

[75] Zahra, N., Hafeez, M.B., Ghaffar, A., et al., 2023. Plant photosynthesis under heat stress: Effects and management. Environmental and Experimental Botany. 206, 105178. DOI: https://doi.org/10.1016/j.envexpbot.2022.105178

[76] Collado, C.E., Hwang, S.J., Hernández, R., 2024. Supplemental greenhouse lighting increased the water use efficiency, crop growth, and cutting production in Cannabis sativa. Frontiers in Plant Science. 15, 1371702. DOI: https://doi.org/10.3389/fpls.2024.1371702

[77] Duong, H., Pearson, B., Anderson, S., et al., 2023. Variation in Hydric Response of Two Industrial Hemp Varieties (Cannabis sativa) to Induced Water Stress. Horticulturae. 9(4), 431. DOI: https://doi.org/10.3390/horticulturae9040431

[78] Zheng, Y., 2022. Rootzone Management in Cannabis Production. In: Handbook of Cannabis Production in Controlled Environments. CRC Press: Boca Raton, FL, USA. pp. 123–162. DOI: https://doi.org/10.1201/9781003150442-5

[79] Payment, J., Cvetkovska, M., 2023. The responses of Cannabis sativa to environmental stress: a balancing act. Botany. 101(8), 318–332. DOI: https://doi.org/10.1139/cjb-2023-0056

[80] Sheldon, K., Shekoofa, A., Walker, E., et al., 2021. Physiological screening for drought-tolerance traits among hemp ( Cannabis sativa L.) cultivars in controlled environments and in field. Journal of Crop Improvement. 35(6), 816–831. DOI: https://doi.org/10.1080/15427528.2021.1883175

[81] Stemeroff, J., 2017. Irrigation management strategies for medical cannabis in controlled environments [PhD’s thesis]. University of Guelph: Guelph, ON, Canada. Available from: https://atrium.lib.uoguelph.ca/server/api/core/bitstreams/235b6af3-174c-4dd4-b48a-31660c23f353/content

[82] Mahmoud, M., BenRejeb, I., Punja, Z.K., et al., 2023. Understanding bud rot development, caused by Botrytis cinerea , on cannabis ( Cannabis sativa L.) plants grown under greenhouse conditions. Botany. 101(7), 200–231. DOI: https://doi.org/10.1139/cjb-2022-0139

[83] Eichhorn Bilodeau, S., Wu, B.-S., Rufyikiri, A.-S., et al., 2019. An Update on Plant Photobiology and Implications for Cannabis Production. Frontiers in Plant Science. 10, 296. DOI: https://doi.org/10.3389/fpls.2019.00296

[84] Ahrens, A., Llewellyn, D., Zheng, Y., 2023. Is Twelve Hours Really the Optimum Photoperiod for Promoting Flowering in Indoor-Grown Cultivars of Cannabis sativa? Plants. 12(14), 2605. DOI: https://doi.org/10.3390/plants12142605

[85] Danziger, N., Bernstein, N., 2021. Light matters: Effect of light spectra on cannabinoid profile and plant development of medical cannabis (Cannabis sativa L.). Industrial Crops and Products. 164, 113351. DOI: https://doi.org/10.1016/j.indcrop.2021.113351

[86] Konvalina, P., Neumann, J., Hoang, T.N., et al., 2024. Effect of Light Intensity and Two Different Nutrient Solutions on the Yield of Flowers and Cannabinoids in Cannabis sativa L. Grown in Controlled Environment. Agronomy. 14(12), 2960. DOI: https://doi.org/10.3390/agronomy14122960

[87] Rodriguez-Morrison, V., Llewellyn, D., Zheng, Y., 2021. Cannabis Inflorescence Yield and Cannabinoid Concentration Are Not Increased With Exposure to Short-Wavelength Ultraviolet-B Radiation. Frontiers in Plant Science. 12, 725078. DOI: https://doi.org/10.3389/fpls.2021.725078

[88] Peterswald, T.J., Mieog, J.C., Azman Halimi, R., et al., 2023. Moving Away from 12:12; the Effect of Different Photoperiods on Biomass Yield and Cannabinoids in Medicinal Cannabis. Plants. 12(5), 1061. DOI: https://doi.org/10.3390/plants12051061

[89] Dumani, A., Egbichi, I., Oyedeji, A.O., et al., 2024. Influence of Temperature on Cannabis sativa Seed Germination: Insights from Lusikisiki Ecotypes, Eastern Cape. Asian Journal of Crop Science. 16(1), 6–21. DOI: https://doi.org/10.3923/ajcs.2024.6.21

[90] Holweg, M.M.S.F., Curren, T., Cravino, A., et al., 2025. High air temperature reduces plant specialized metabolite yield in medical cannabis, and has genotype-specific effects on inflorescence dry matter production. Environmental and Experimental Botany. 230, 106085. DOI: https://doi.org/10.1016/j.envexpbot.2025.106085

[91] Chandra, S., Lata, H., ElSohly, M.A., 2020. Propagation of Cannabis for Clinical Research: An Approach Towards a Modern Herbal Medicinal Products Development. Frontiers in Plant Science. 11, 958. DOI: https://doi.org/10.3389/fpls.2020.00958

[92] Punja, Z.K., Collyer, D., Scott, C., et al., 2019. Pathogens and Molds Affecting Production and Quality of Cannabis sativa L. Frontiers in Plant Science. 10, 1120. DOI: https://doi.org/10.3389/fpls.2019.01120

[93] Morgan, W., Singh, J., Kesheimer, K., et al., 2024. Severe drought significantly reduces floral hemp (Cannabis sativa L.) yield and cannabinoid content but moderate drought does not. Environmental and Experimental Botany. 219, 105649. DOI: https://doi.org/10.1016/j.envexpbot.2024.105649

[94] Fusaro, M.C., Lucchetta, I., Bona, S., 2025. Water Stress Effects on Biomass Allocation and Secondary Metabolism in CBD-Dominant Cannabis sativa L. Plants. 14(8), 1267. DOI: https://doi.org/10.3390/plants14081267

[95] Velechovský, J., Malík, M., Šenkyřík, J.B., et al., 2024. Effect of augmented nutrient composition and fertigation system on biomass yield and cannabinoid content of medicinal cannabis (Cannabis sativa L.) cultivation. Frontiers in Plant Science. 15, 1322824. DOI: https://doi.org/10.3389/fpls.2024.1322824

[96] Wielgusz, K., Praczyk, M., Irzykowska, L., et al., 2022. Fertilization and soil pH affect seed and biomass yield, plant morphology, and cadmium uptake in hemp (Cannabis sativa L.). Industrial Crops and Products. 175, 114245. DOI: https://doi.org/10.1016/j.indcrop.2021.114245

[97] Romanazzi, G., Feliziani, E., 2014. Botrytis cinerea (Gray Mold). In: Postharvest Decay. Elsevier: London, UK. pp. 131–146. DOI: https://doi.org/10.1016/B978-0-12-411552-1.00004-1

[98] Bevan, L., Jones, M., Zheng, Y., 2021. Optimisation of Nitrogen, Phosphorus, and Potassium for Soilless Production of Cannabis sativa in the Flowering Stage Using Response Surface Analysis. Frontiers in Plant Science. 12, 764103. DOI: https://doi.org/10.3389/fpls.2021.764103

[99] Nguyen, G.N., Norton, S.L., 2020. Genebank Phenomics: A Strategic Approach to Enhance Value and Utilization of Crop Germplasm. Plants. 9(7), 817. DOI: https://doi.org/10.3390/plants9070817

[100] Barcaccia, G., 2010. Molecular Markers for Characterizing and Conserving Crop Plant Germplasm. In: Jain, S.M., Brar, D.S. (Eds.). Molecular Techniques in Crop Improvement. Springer: Dordrecht, Netherlands. pp. 231–254. DOI: https://doi.org/10.1007/978-90-481-2967-6_10

[101] Lutatenekwa, D.L., Mtengeti, E.J., Msalya, G.M., 2020. A review of plant characterization: First step towards sustainable forage production in challenging environments. African Journal of Plant Science. 14(9), 350–357. DOI: https://doi.org/10.5897/AJPS2020.2041

[102] Sahu, P.K., Sao, R., Khute, I.K., et al., 2023. Plant Genetic Resources: Conservation, Evaluation and Utilization in Plant Breeding. In: Raina, A., Wani, M.R., Laskar, R.A., et al. (Eds.). Advanced Crop Improvement, Volume 2. Springer International Publishing: Cham, Switzerland. pp. 1–45. DOI: https://doi.org/10.1007/978-3-031-26669-0_1

[103] Meitei, K.M., Bora, G.C., Singh, S.J., et al., 2014. Morphology based genetic variability analysis and identification of important characters for tomato (Solanum lycopersicum L.) Crop improvement. American-Eurasian Journal of Agricultural and Environmental Sciences. 14(10), 1105–1111. Available from: https://www.idosi.org/aejaes/jaes14(10)14/21.pdf

[104] Emam, M.A., Abd EL-Mageed, A.M., Niedbała, G., et al., 2022. Genetic Characterization and Agronomic Evaluation of Drought Tolerance in Ten Egyptian Wheat (Triticum aestivum L.) Cultivars. Agronomy. 12(5), 1217. DOI: https://doi.org/10.3390/agronomy12051217

[105] Khalid, A., Hameed, A., 2017. Seed Biochemical Analysis Based Profiling of Diverse Wheat Genetic Resource from Pakistan. Frontiers in Plant Science. 8, 1276. DOI: https://doi.org/10.3389/fpls.2017.01276

[106] Alhasnawi, A.N., Alasadiy, Y.D.K., Doni, F., 2024. Assessment of the genetic diversity in plants using molecular markers: a review and perspective. Tropical Agriculture. 101(1), 120–134. Available from: https://journals.sta.uwi.edu/ojs/index.php/ta/article/view/8593

[107] Ab-Shukor, N.A., 2001. Biochemical markers in plant genetic resources characterization. In: Saad, M.S., Rao, V.R. (Eds.). Establishment and Management of Field Genebank, a Training Manual. IPGRI: Rome, Italy. p.95. Available from: https://genebanks.cgiar.org/wp-content/uploads/2009/04/fieldbank_manual.pdf (cited 06 May 2025).

[108] Herrera, C.M., 2017. The ecology of subindividual variability in plants: patterns, processes, and prospects. Web Ecology. 17(2), 51–64. DOI: https://doi.org/10.5194/we-17-51-2017

[109] Quazi, S., Golani, T., Martino Capuzzo, A., 2021. Germplasm Conservation. In: Kumar, S. (Ed.). Endangered Plants. IntechOpen: London, UK. DOI: https://doi.org/10.5772/intechopen.96184

[110] Gulati, R., 2018. Strategies for sustaining plant germplasm evaluation and conservation a review. Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences, 4(5), 313–320.

[111] Cooper, M., Messina, C.D., 2023. Breeding crops for drought-affected environments and improved climate resilience. The Plant Cell. 35(1), 162–186. DOI: https://doi.org/10.1093/plcell/koac321

[112] Hafeez, A., Ali, B., Javed, M.A., et al., 2023. Plant breeding for harmony between sustainable agriculture, the environment, and global food security: an era of genomics‐assisted breeding. Planta. 258(5), 97. DOI: https://doi.org/10.1007/s00425-023-04252-7

[113] Cabahug, R.A.M., Nam, S.Y., et al., 2018. Propagation Techniques for Ornamental Succulents. Flower Research Journal. 26(3), 90–101. DOI: https://doi.org/10.11623/frj.2018.26.3.02

[114] Kassahun, B.M., Mekonnen, S.A., 2011. Effect of cutting position and rooting hormone on propagation ability of stevia (Stevia rebaudiana Bertoni). The African Journal of Plant Science and Biotechnology. 6(1), 5–8. Available from: https://www.researchgate.net/publication/276275944_Effect_of_Cutting_Position_and_Rooting_Hormone_on_Propagation_Ability_of_Stevia_Stevia_rebaudiana_Bertoni

[115] Potter, D. 2009. The propagation, characterisation and optimisation of Cannabis sativa L. as a phytopharmaceutical [PhD’s thesis]. King’s College London: London, UK. Available from: https://extractionmagazine.com/wp-content/uploads/2018/06/THE-PROPAGATION-CHARACTERISATION-AND-OPTIMISATION-OF-CANNABIS-SATIVA-L-AS-A-PHYTOPHARMACEUTICAL.pdf

[116] Lata, H., Chandra, S., Mehmadic, Z., et al., 2011. In vitro Germplasm Conservation of High THC Yielding Elite Clones of Cannabis sativa L. under Slow Growth Conditions. Planta Medica. 77(05), s-0031-1273532. DOI: https://doi.org/10.1055/s-0031-1273532

[117] Simiyu, D.C., Jang, J.H., Lee, O.R., 2022. Understanding Cannabis sativa L.: Current Status of Propagation, Use, Legalization, and Haploid-Inducer-Mediated Genetic Engineering. Plants. 11(9), 1236. DOI: https://doi.org/10.3390/plants11091236

[118] Hartmann, H.T., Kester, D.E., 2011. Plant propagation: principles and practices, 8th ed. Prentice-Hall: Hoboken, NJ, USA.

[119] Beyl, C.A., Sharma, G.C., 2016. Plant physiology concepts important for propagation success. In: Beyl, C.A., Trigiano, R.N. (Eds.) Plant Propagation Concepts and Laboratory Exercises. CRC Press: New York, NY, USA. pp.29–46. DOI: https://doi.org/10.1201/b17340

[120] Soorni, A., Fatahi, R., Haak, D.C., et al., 2017. Assessment of Genetic Diversity and Population Structure in Iranian Cannabis Germplasm. Scientific Reports. 7(1), 15668. DOI: https://doi.org/10.1038/s41598-017-15816-5

[121] Mendoza, M.A., Mills, D.K., Lata, H., et al., 2009. Genetic individualization of Cannabis sativa by a short tandem repeat multiplex system. Analytical and Bioanalytical Chemistry. 393(2), 719–726. DOI: https://doi.org/10.1007/s00216-008-2500-3

[122] Raman, V., Lata, H., Chandra, S., et al., 2017. Morpho-Anatomy of Marijuana (Cannabis sativa L.). In: Chandra, S., Lata, H., ElSohly, M.A. (Eds.). Cannabis Sativa L—Botany and Biotechnology. Springer International Publishing: Cham, Switzerland. pp. 123–136. DOI: https://doi.org/10.1007/978-3-319-54564-6_5

[123] Condic, M.L., 2014. Totipotency: What It Is and What It Is Not. Stem Cells and Development. 23(8), 796–812. DOI: https://doi.org/10.1089/scd.2013.0364

[124] Le, R., Huang, Y., Zhao, A., et al., 2020. Lessons from expanded potential of embryonic stem cells: Moving toward totipotency. Journal of Genetics and Genomics. 47(3), 123–130. DOI: https://doi.org/10.1016/j.jgg.2020.02.003

[125] Machel A. Emanuel, Valrick V. Henry, Dwight E. Robinson, 2020. Vegetative growth of Cannabis sativa L. cultivars in Jamaica using 18/6 photoperiod. International Journal of Plant Science and Horticulture. 56–64. DOI: https://doi.org/10.36811/ijpsh.2020.110024

[126] Yadav, D., Singh, S.P., 2018. Vegetative methods of plant propagation: I-cutting layering and budding. Journal of Pharmacognosy and Phytochemistry. 7(2), 3267–3273.

[127] Awotedu, B.F., Omolola, T.O., Akala, A.O., et al., 2021. Vegetative propagation: A unique technique of improving plants growth. World News of Natural Sciences. 35, 83–101.

[128] Hossain, M.A., Islam, M.A., Azad, M.A.K., et al., 2019. Propagation of an Endangered Gymnosperm Tree Species (Podocarpus neriifolius D. Don.) by Stem Cuttings in a Non-mist Propagator. Pertanika Journal of Tropical Agricultural Science. 42(1). Available from: https://www.researchgate.net/publication/332093216_Propagation_of_an_endangered_gymnosperm_tree_species_podocarpus_neriifolius_d_don_by_stem_cuttings_in_non-mist_propagator

[129] Gorelick, R., 2015. Why Vegetative Propagation of Leaf Cuttings is Possible in Succulent and Semi-Succulent Plants. Haseltonia. 20, 51–57. DOI: https://doi.org/10.2985/026.020.0109

[130] Santoso, B.B., Parwata, I.G.A., 2014. Seedling growth from stem cutting with different physiological ages of Jatropha curcas L. of West Nusa Tenggara genotypes. International Journal of Applied. 4(6). Available from: https://www.researchgate.net/publication/293822460_Seedling_Growth_from_Stem_Cutting_with_Different_Physiological_Ages_of_Jatropha_curcas_L_of_West_Nusa_Tenggara_Genotypes

[131] Oseni, O.M., Pande, V., Nailwal, T.K., 2018. A Review on Plant Tissue Culture, A Technique for Propagation and Conservation of Endangered Plant Species. International Journal of Current Microbiology and Applied Sciences. 7(07), 3778–3786. DOI: https://doi.org/10.20546/ijcmas.2018.707.438

[132] Ibarra-Lecue, I., Pilar-Cuéllar, F., Muguruza, C., et al., 2018. The endocannabinoid system in mental disorders: Evidence from human brain studies. Biochemical Pharmacology. 157, 97–107. DOI: https://doi.org/10.1016/j.bcp.2018.07.009

[133] Mostafaei Dehnavi, M., Ebadi, A., Peirovi, A., et al., 2022. THC and CBD Fingerprinting of an Elite Cannabis Collection from Iran: Quantifying Diversity to Underpin Future Cannabis Breeding. Plants. 11(1), 129. DOI: https://doi.org/10.3390/plants11010129

[134] Datwyler, S.L., Weiblen, G.D., 2006. Genetic Variation in Hemp and Marijuana ( Cannabis sativa L.) According to Amplified Fragment Length Polymorphisms. Journal of Forensic Sciences. 51(2), 371–375. DOI: https://doi.org/10.1111/j.1556-4029.2006.00061.x

[135] Dimopoulos, N., Guo, Q., Purdy, S.J., et al., 2025. From dawn ‘til dusk: daytime progression regulates primary and secondary metabolism in Cannabis glandular trichomes. Journal of Experimental Botany. 76(1), 134–151. DOI: https://doi.org/10.1093/jxb/erae148

[136] Odieka, A.E., Obuzor, G.U., Oyedeji, O.O., et al., 2022. The Medicinal Natural Products of Cannabis sativa Linn.: A Review. Molecules. 27(5), 1689. DOI: https://doi.org/10.3390/molecules27051689

[137] Milay, L., Berman, P., Shapira, A., et al., 2020. Metabolic Profiling of Cannabis Secondary Metabolites for Evaluation of Optimal Postharvest Storage Conditions. Frontiers in Plant Science. 11, 583605. DOI: https://doi.org/10.3389/fpls.2020.583605

[138] Gigliano, G.S., 2001. Cannabis sativa L.-Botanical Problems and Molecular Approaches in Forensic Investigation. Forensic Science Review. 13(1), 1–17.

[139] Taura, F., Sirikantaramas, S., Shoyama, Yoshinari, et al., 2007. Cannabidiolic‐acid synthase, the chemotype‐determining enzyme in the fiber‐type Cannabis sativa. FEBS Letters. 581(16), 2929–2934. DOI: https://doi.org/10.1016/j.febslet.2007.05.043

[140] Upton, R., Craker, L., ElSohly, M., et al., 2014. Cannabis inflorescence: Standards of identity, analysis, and quality control. American Herbal Pharmacopoeia: Scotts Valley, CA, USA. pp.1–15.

[141] Vlad, R.A., Hancu, G., Ciurba, A., et al., 2020. Cannabidiol-therapeutic and legal aspects. Die Pharmazie-An International Journal of Pharmaceutical Sciences. 75(10), 463–469. Available from: https://www.ingentaconnect.com/content/govi/pharmaz/2020/00000075/00000010/art00002;jsessionid=12a2y7wxa8u8r.x-ic-live-02

[142] Bolognini, D., Costa, B., Maione, S., et al., 2010. The plant cannabinoid Δ9 ‐tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice. British Journal of Pharmacology. 160(3), 677–687. DOI: https://doi.org/10.1111/j.1476-5381.2010.00756.x

[143] Lindner, T., Schmidl, D., Peschorn, L., et al., 2023. Therapeutic Potential of Cannabinoids in Glaucoma. Pharmaceuticals. 16(8), 1149. DOI: https://doi.org/10.3390/ph16081149

[144] Blasco-Benito, S., Seijo-Vila, M., Caro-Villalobos, M., et al., 2018. Appraising the “entourage effect”: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer. Biochemical Pharmacology. 157, 285–293. DOI: https://doi.org/10.1016/j.bcp.2018.06.025

[145] Baselga, J., Coleman, R.E., Cortés, J., et al., 2017. Advances in the management of HER2-positive early breast cancer. Critical Reviews in Oncology/Hematology. 119, 113–122. DOI: https://doi.org/10.1016/j.critrevonc.2017.10.001

[146] Jin, D., Dai, K., Xie, Z., et al., 2020. Secondary Metabolites Profiled in Cannabis Inflorescences, Leaves, Stem Barks, and Roots for Medicinal Purposes. Scientific Reports. 10(1), 3309. DOI: https://doi.org/10.1038/s41598-020-60172-6

[147] Caplan, B., 2023. The Doctor-Approved Cannabis Handbook: Reverse Disease, Treat Pain, and Enhance Your Wellness with Medical Marijuana and CBD. BenBella Books: Dallas, TX, USA.

[148] Bereketoglu, C., 2020. Delivery of medicinal cannabis. Available from: https://www.um.edu.mt/library/oar/handle/123456789/72634 (cited 24 May 2025).

[149] Vilke, G.M., Ly, B.T., 2022. Clinical Syndromes and Emergency Room Physician and Management Issues. In: Karch’s Drug Abuse Handbook. CRC Press: Boca Raton, FL, USA. pp. 1–132. DOI: https://doi.org/10.4324/9781315155159-1

[150] Wong, K.U., Baum, C.R., 2019. Acute Cannabis Toxicity. Pediatric Emergency Care. 35(11), 799–804. DOI: https://doi.org/10.1097/PEC.0000000000001970

[151] Potter, B.A., 2018. Cannabis for Canines. Ronin Publishing: Berkeley, CA, USA.

[152] Shinde, T., Hansbro, P.M., Sohal, S.S., et al., 2020. Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives. Microorganisms. 8(6), 921. DOI: https://doi.org/10.3390/microorganisms8060921

[153] Bijauliya, R.K., Alok, S., Singh, M., et al., 2017. A comprehensive review on cancer and anticancer herbal drugs. International Journal Of Pharmaceutical Sciences And Research. 8(7), 2740–2761. Available from: https://www.researchgate.net/publication/318082530_A_COMPREHENSIVE_REVIEW_ON_CANCER_AND_ANTICANCER_HERBAL_DRUGS

[154] Grotenhermen, F., 2020. Cannabis Healing: A Guide to the Therapeutic Use of CBD, THC, and Other Cannabinoids. Simon and Schuster: New York, NY, USA.

[155] Louis, B.W.-St. (Ed.), 2018. Cannabis: A Clinician’s Guide, 1st ed. CRC Press: Boca Raton, FL, USA. DOI: https://doi.org/10.1201/9780203730591

[156] Blebea, N.M., Pricopie, A.I., Vlad, R.-A., et al., 2024. Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use. International Journal of Molecular Sciences. 25(8), 4204. DOI: https://doi.org/10.3390/ijms25084204

[157] Gonçalves, J., Rosado, T., Soares, S., et al., 2019. Cannabis and Its Secondary Metabolites: Their Use as Therapeutic Drugs, Toxicological Aspects, and Analytical Determination. Medicines. 6(1), 31. DOI: https://doi.org/10.3390/medicines6010031

[158] Sepulveda, D.E., Vrana, K.E., Kellogg, J.J., et al., 2024. The Potential of Cannabichromene (CBC) as a Therapeutic Agent. The Journal of Pharmacology and Experimental Therapeutics. 391(2), 206–213. DOI: https://doi.org/10.1124/jpet.124.002166

[159] Hong, M., Kim, J.-H., Han, J.-H., et al., 2023. In Vitro and In Vivo Anti-Inflammatory Potential of Cannabichromene Isolated from Hemp. Plants. 12(23), 3966. DOI: https://doi.org/10.3390/plants12233966

[160] Baron, E.P., 2018. Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science. Headache: The Journal of Head and Face Pain. 58(7), 1139–1186. DOI: https://doi.org/10.1111/head.13345

[161] Oultram, J.M.J., Pegler, J.L., Bowser, T.A., et al., 2021. Cannabis sativa: Interdisciplinary Strategies and Avenues for Medical and Commercial Progression Outside of CBD and THC. Biomedicines. 9(3), 234. DOI: https://doi.org/10.3390/biomedicines9030234

[162] Li, H., Liu, Y., Tian, D., et al., 2020. Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer’s disease. European Journal of Medicinal Chemistry. 192, 112163. DOI: https://doi.org/10.1016/j.ejmech.2020.112163

[163] Zamberletti, E., Rubino, T., Parolaro, D., 2021. Therapeutic potential of cannabidivarin for epilepsy and autism spectrum disorder. Pharmacology & Therapeutics. 226, 107878. DOI: https://doi.org/10.1016/j.pharmthera.2021.107878

[164] Alves, P., Amaral, C., Teixeira, N., et al., 2020. Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol. Pharmacological Research. 157, 104822. DOI: https://doi.org/10.1016/j.phrs.2020.104822

[165] Maumela, M.R., Nkondo, L.G., 2024. Potential cannabis commercialisation benefits in the South Africa cannabis masterplan. International Journal of Business Ecosystem & Strategy (2687-2293). 6(4), 70–81. DOI: https://doi.org/10.36096/ijbes.v6i4.634

[166] Raihan, A., Bijoy, T.R., 2023. A review of the industrial use and global sustainability of Cannabis sativa. Global Sustainability Research. 2(4), 1–29. DOI: https://doi.org/10.56556/gssr.v2i4.597

[167] Quarshie, E., 2022. Implication of Regulated Cannabis Legalisation on Wellbeing and Economic Growth [PhD’s thesis]. University of the Witwatersrand: Johannesburg, South Africa. Available from: https://www.nilevalleymultiversity.com/uploads/PhD_Proposal_Emmanuel%20Quarshie.pdf

[168] Panchalingam, T., Cooper, M., Shang, C., et al., 2023. Behavioral economic relationship between cannabis flower and concentrates: Evidence from simulated purchase tasks. Experimental and Clinical Psychopharmacology. 31(3), 694–703. DOI: https://doi.org/10.1037/pha0000618

[169] Salehi, A., Puchalski, K., Shokoohinia, Y., et al., 2022. Differentiating Cannabis Products: Drugs, Food, and Supplements. Frontiers in Pharmacology. 13, 906038. DOI: https://doi.org/10.3389/fphar.2022.906038

[170] Zimniewska, M., 2022. Hemp Fibre Properties and Processing Target Textile: A Review. Materials. 15(5), 1901. DOI: https://doi.org/10.3390/ma15051901

[171] Litvinova, O., Baral, B., Wochele-Thoma, T., et al., 2024. Efficiency and safety of cannabinoid medical use: an analysis of discussions and observed trends on Instagram. Frontiers in Public Health. 12, 1494018. DOI: https://doi.org/10.3389/fpubh.2024.1494018

[172] Waetjen, T., 2024. Thinking about drugs histories and private purposes in South Africa. Acta Academica: Critical views on society, culture and politics. 56(1). DOI: https://doi.org/10.38140/aa.v56i1.8411

[173] Oriola, A.O., Kar, P., Oyedeji, A.O., 2024. Cannabis sativa as an Herbal Ingredient: Problems and Prospects. Molecules. 29(15), 3605. DOI: https://doi.org/10.3390/molecules29153605

[174] Alpina, E., 2023. Cannabis Statistics Roundup for 2024. https://trym.io/tag/business/ accessed on 05 September 2025.

[175] Market Growth Report, 2025. Cannabis Cultivation Market Overview. Available from: https://www.marketgrowthreports.com/market-reports/cannabis-cultivation-market-106345 (cited 29 June 2025).

[176] Malabadi, R.B., Mammadova, S.S., Kolkar, K.P., et al., 2024. Cannabis sativa: A therapeutic medicinal plant-global marketing updates. World Journal of Biology Pharmacy and Health Sciences. 17(2), 170–183. DOI: https://doi.org/10.30574/wjbphs.2024.17.2.0044

[177] Huseynova, A., Mazanova, O., Mammadova, S., et al., 2022. Analysis of the Relationship Between the Economic Confidence Index and GDP Growth in Azerbaijan. WSEAS TRANSACTIONS ON BUSINESS AND ECONOMICS. 19, 867–875. DOI: https://doi.org/10.37394/23207.2022.19.75

[178] United Nations Office on Drugs and Crime (UNDC), 2024. World Drug Report 2024 (Set of 3 Booklets). Available from: https://www.unodc.org/unodc/data-and-analysis/world-drug-report-2024.html (cited 19 June 2025).

[179] European Union Drugs Agency (EUDA), 2023. EU Drug Market: Cannabis — In-depth analysis. Available from: https://www.euda.europa.eu/publications/eu-drug-markets/cannabis_en (cited 30 May 2025).

[180] Nabil, E.B., Metouekel, A., Serondo, H., et al., 2024. Cannabis unveiled: From history to innovation exploring the world of cannabis strains chemistry industry and economic impact. Chemical Review and Letters. 7(9). DOI: https://doi.org/10.22034/crl.2024.449414.1314

[181] Niloy, N., Hediyal, T.A., Vichitra, C., et al., 2023. Effect of Cannabis on Memory Consolidation, Learning and Retrieval and Its Current Legal Status in India: A Review. Biomolecules. 13(1), 162. DOI: https://doi.org/10.3390/biom13010162