CRISPR/Cas-Mediated Genome Editing for Enhancing Abiotic Stress Tolerance in Major Food Crops: Recent Advances and Future Perspectives

Mayank Anand Guru Rani S

Biology Department, College of Science, United Arab Emirates University, Al Ain 15551, United Arab Emirates


Abstract

Abiotic stresses (drought, salinity, heat, cold) severely limit crop productivity, threatening global food security amid climate change and population growth. CRISPR/Cas genome editing has emerged as a precise, efficient tool for crop improvement. This review summarizes recent (2022–2025) advances in CRISPR/Cas-mediated modification of abiotic stress-responsive genes in rice, wheat, maize, and soybean. It discusses editing strategies, trait enhancement effects, and challenges in translation. We highlight how integrated multi-omics and AI optimize editing efficiency, providing insights for sustainable agricultural biotechnology.